{"id":2228,"date":"2018-10-12T21:13:06","date_gmt":"2018-10-12T12:13:06","guid":{"rendered":"http:\/\/xn--rov785aa3148a.com\/?p=2228"},"modified":"2020-05-26T18:00:06","modified_gmt":"2020-05-26T09:00:06","slug":"%e7%99%bd%e9%ab%aa%e3%81%ae%e5%8e%9f%e5%9b%a0%e3%81%a8%e9%81%ba%e4%bc%9d%e3%81%ae%e8%a7%a3%e6%98%8e%ef%bc%81%e5%8c%bb%e5%ad%a6%e5%a4%a7%e8%be%9e%e5%85%b8%e3%80%8c%e5%85%88%e5%a4%a9%e6%80%a7%e7%99%bd","status":"publish","type":"post","link":"https:\/\/xn--rov785aa3148a.com\/?p=2228","title":{"rendered":"\u751f\u307e\u308c\u3064\u304d\u306e\u767d\u9aea\u4f53\u8cea\uff5e\u533b\u5b66\u5927\u8f9e\u5178\u300c\u5148\u5929\u6027\u767d\u6bdb\u300d\u306e\u5168\u6587\u3092\u89e3\u8aad\u3059\u308b\uff01"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-4112\" src=\"https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2018\/10\/9882cecf8d7aa02bdcd57bee115da335.png\" alt=\"\" width=\"750\" height=\"486\" 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src=\"http:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/04\/4b4795c191f75746601e344e321d9f4f.png\" alt=\"\" width=\"500\" height=\"303\" srcset=\"https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/04\/4b4795c191f75746601e344e321d9f4f.png 1538w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/04\/4b4795c191f75746601e344e321d9f4f-150x91.png 150w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/04\/4b4795c191f75746601e344e321d9f4f-768x465.png 768w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/>\u51fa\u5178\uff1a\u5357\u5c71\u5802 \u533b\u5b66\u5927\u8f9e\u5178 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C45A2\u907a\u4f1d\u5b50\u3001C10ORF11\u907a\u4f1d\u5b50\u3001SL C24A 5\u907a\u4f1d\u5b50\uff09\u3001\u75c7\u5019\u578b\uff08\u5168\u8eab\u306b\u75c7\u72b6\u304c\u73fe\u308c\u308b\u3082\u306e\uff09\u3068\u3057\u306613\u7a2e\u985e\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u304c\u540c\u3058\u3067\u3082\u3001\u75c7\u72b6\u304c\u591a\u5f69\uff08\u751f\u6daf\u307b\u3068\u3093\u3069\u30e1\u30e9\u30cb\u30f3\u3092\u5408\u6210\u3057\u306a\u3044\u75c7\u4f8b\u304b\u3089\u3001\u5065\u5e38\u306e\u4eba\u3068\u307b\u3068\u3093\u3069\u540c\u3058\u30ec\u30d9\u30eb\u307e\u3067\u30e1\u30e9\u30cb\u30f3\u3092\u5408\u6210\u3059\u308b\u75c7\u4f8b\u307e\u3067\uff09\u3067\u3001\u3057\u304b\u3082\u7570\u306a\u308b\u30bf\u30a4\u30d7\u3067\u3082\u75c7\u72b6\u304c\u91cd\u306a\u308b\u305f\u3081\u3001\u75c7\u72b6\u3060\u3051\u304b\u3089\u539f\u56e0\u306e\u907a\u4f1d\u5b50\u3092\u7279\u5b9a\u3059\u308b\u306e\u306f\u56f0\u96e3\u3067\u3059\u3002<\/p>\n<p>\u75c5\u6c17\u306e\u30bf\u30a4\u30d7\u3092\u5206\u985e\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b50\u8a3a\u65ad\u304c\u5fc5\u9808\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u75c7\u5019\u578b\uff08\u5168\u8eab\u306b\u75c7\u72b6\u304c\u73fe\u308c\u308b\u3082\u306e\uff09\u306b\u306f\u3001\u30d8\u30eb\u30de\u30f3\u30b9\u30ad\u30fc\u30fb\u30d1\u30c9\u30e9\u30c3\u30af\u75c7\u5019\u7fa4\u3001\u30c1\u30a7\u30c7\u30a3\u30a2\u30c3\u30af\u30fb\u6771\u75c7\u5019\u7fa4\u3001\u30b0\u30ea\u30bb\u30ea\u75c7\u5019\u7fa4\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u983b\u5ea6\u306f\u975e\u75c7\u5019\u578b\uff08\u5168\u8eab\u306b\u75c7\u72b6\u304c\u73fe\u308c\u306a\u3044\u3082\u306e\uff09\u306e\u7d0410\u5206\u306e1\u7a0b\u5ea6\u3067\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u6587\u4e2d\u306b\u51fa\u3066\u304f\u308b\u5404\u75c7\u5019\u7fa4\u306f\u3001\u75c5\u6c17\u30bf\u30a4\u30d7\u306e\u540d\u524d\u3067\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u30e1\u30e9\u30cb\u30f3\u306e\u5408\u6210\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u306b\u3088\u308b\u75c7\u72b6\u306e\u4ed6\u306b\u3001\u30d8\u30eb\u30de\u30f3\u30b9\u30ad\u30fc\u30fb\u30d1\u30c9\u30e9\u30c3\u30af\u75c7\u5019\u7fa4\u306e\u5834\u5408\u306f\u51fa\u8840\u306e\u50be\u5411\u3001\u30c1\u30a7\u30c7\u30a3\u30a2\u30c3\u30af\u30fb\u6771\u75c7\u5019\u7fa4\u306e\u5834\u5408\u306f\u597d\u4e2d\u7403\u6027\u514d\u75ab\u4e0d\u5168\u3001\u30b0\u30ea\u30bb\u30ea\u75c7\u5019\u7fa4\u306e\u5834\u5408\u306f\u795e\u7d4c\u969c\u5bb3\u3084\u514d\u75ab\u7570\u5e38\u3092\u4f75\u767a\u3057\u307e\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u597d\u4e2d\u7403\u306f\u767d\u8840\u7403\u306e1\u7a2e\u985e\u3067\u3001\u30ab\u30e9\u30c0\u306b\u4fb5\u5165\u3057\u3066\u304d\u305f\u7d30\u83cc\u306a\u3069\u3092\u6bba\u83cc\u3057\u3066\u3001\u611f\u67d3\u3092\u9632\u304e\u307e\u3059\u3002\u597d\u4e2d\u7403\u304c\u6e1b\u308b\u3068\u3001\u611f\u67d3\u75c7\u306b\u304b\u304b\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<h2>\u751f\u307e\u308c\u3064\u304d\u306e\u767d\u9aea\u4f53\u8cea\uff5e\u65e9\u8001\u75c7\u5019\u7fa4<\/h2>\n<p>\u751f\u307e\u308c\u3064\u304d\u306e\u767d\u9aea\u4f53\u8cea\u3001\u65e9\u8001\u75c7\u5019\u7fa4\u3068\u3057\u3066\u63b2\u8f09\u3055\u308c\u3066\u3044\u308b\u306e\u306f2\u9805\u76ee\u3067\u3059\u3002<\/p>\n<p>\u305d\u308c\u305e\u308c\u306e\u9805\u76ee\u3092\u3001\u533b\u5b66\u5927\u8f9e\u5178\u3067\u53c2\u7167\u3057\u3066\u3001\u8aad\u307f\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<h3>\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4<\/h3>\n<p>\u65e9\u8001\u75c7\u5019\u7fa4\u306e\u6700\u521d\u306f\u3001\u300c\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u300d\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2230\" src=\"http:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/2a9183cd112bde152691b0686294098d.png\" alt=\"\" width=\"350\" height=\"398\" srcset=\"https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/2a9183cd112bde152691b0686294098d.png 965w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/2a9183cd112bde152691b0686294098d-132x150.png 132w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/2a9183cd112bde152691b0686294098d-768x873.png 768w\" sizes=\"auto, (max-width: 350px) 100vw, 350px\" \/>\u51fa\u5178\uff1a\u5357\u5c71\u5802 \u533b\u5b66\u5927\u8f9e\u5178 185\u30fb186\u30da\u30fc\u30b8<\/p>\n<p>&nbsp;<\/p>\n<p>1904\u5e74\u306bWerner \u304c\u300c\u5f37\u76ae\u75c7\u3092\u4f75\u767a\u3057\u305f\u767d\u5185\u969c\u300d\u3092\u5831\u544a\u3057\u3066\u30011934\u5e74\u306b\u306f\u540c\u3058\u3088\u3046\u306a\u7279\u5fb4\u304c\u3042\u308b\u75be\u60a3\u3092\u72ec\u7acb\u306e\u75c7\u5019\u7fa4\u3068\u3057\u3066\u3001\u300c\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\uff08WRN\uff09\u300d\u3068\u547d\u540d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u73fe\u5728\u307e\u3067\u306b\u3001\u4e16\u754c\u4e2d\u3067\u7d041,200\u4f8b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u4e2d\u3067\u3001\u65e5\u672c\u3067\u306e\u5831\u544a\u304c80\uff05\u3092\u8d85\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u5e38\u67d3\u8272\u4f53\u306b\u304a\u3051\u308b\u52a3\u6027\u907a\u4f1d\u306e\u75be\u60a3\u3067\u3001\u65e5\u672c\u306e\u75c7\u4f8b\u3067\u306f\u3001\u300c\u8fd1\u89aa\u5a5a\u300d\u3068\u304f\u306b\u300c\u3044\u3068\u3053\u5a5a\u300d\u306b\u3088\u308b\u60a3\u8005\u306e\u4f8b\u304c\u591a\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u907a\u4f1d\u5b50\uff08WRN\u907a\u4f1d\u5b50\uff09\u306f\u3001OMIM\uff08Online Mendelian Inheritance in Man\uff09\u756a\u53f7604611\uff08OMIM\u306f\u3001\u30aa\u30f3\u30e9\u30a4\u30f3\u5316\u3055\u308c\u305f\u30d2\u30c8\u907a\u4f1d\u75c5\u306e\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3067\u3059\uff09\u3002<\/p>\n<p>1996 \u5e74\u306b\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u3001RecQ\u578bDNA\u30d8\u30ea\u30ab\u30fc\u30bc\uff08RecQ proteinllke 2;RECQL2\uff09\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3001\u30b3\u30fc\u30c9\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u7d30\u80de\u304c\u6b63\u5e38\u306b\u5206\u88c2\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u907a\u4f1d\u5b50\u306e2\u91cd\u3089\u305b\u3093\u69cb\u9020\u3092\u3001\u3044\u3063\u305f\u3093\u307b\u3069\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u307b\u3069\u304f\u6a5f\u80fd\u3092\u3001\u30d8\u30ea\u30ab\u30fc\u30bc\u3068\u3044\u3046\u9175\u7d20\u304c\u884c\u3044\u307e\u3059\u3002<\/p>\n<p>RecQ\u578bDNA\u30d8\u30ea\u30ab\u30fc\u30bc\u3068\u306f\u3001\u5927\u8178\u83cc\u304b\u3089\u30d2\u30c8\u307e\u3067\u5e83\u304f\u4fdd\u6709\u3059\u308b\u9175\u7d20\u3067\u3001WRN \u30d8\u30ea\u30ab\u30fc\u30bc\u306f\u305d\u306e1\u7a2e\u3067\u3059\u3002\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u306f\u3001WRN \u30d8\u30ea\u30ab\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3001WRN \u30d8\u30ea\u30ab\u30fc\u30bc\u304c\u6a5f\u80fd\u3057\u306a\u304f\u306a\u308b\u3053\u3068\u304c\u539f\u56e0\u3067\u3042\u308b\u3001\u3068\u3044\u3046\u610f\u5473\u306b\u306a\u308a\u307e\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u306e\u539f\u56e0\u3068\u306a\u308b\u3001WRN\u907a\u4f1d\u5b50\u306emRNA \u306f\u7d045.8kb \u306e\u5927\u304d\u3055\u3067\u3001\u307b\u3068\u3093\u3069\u3059\u3079\u3066\u306e\u7d44\u7e54\u3067\u50cd\u304d\u307e\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u907a\u4f1d\u60c5\u5831\u306f\u3001\u3044\u3063\u305f\u3093mRNA\u306b\u8ee2\u5199\u3055\u308c\u3001\u8ee2\u5199\u60c5\u5831\u306b\u3082\u3068\u3065\u3044\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5408\u6210\u3055\u308c\u307e\u3059\u3002kb\u306f\u30ad\u30ed\u30d9\u30fc\u30b9\u3068\u8aad\u307f\u3001\u3053\u306e\u5834\u5408\u306f5800\u500b\u306e\u5316\u5408\u7269\u304c\u4e26\u3093\u3067\u3044\u308b\u3001\u3068\u3044\u3046\u610f\u5473\u306b\u306a\u308a\u307e\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u3053\u308c\u307e\u3067\u306b\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u3001WRN\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f85\u7a2e\u985e\u3042\u3063\u3066\u3001\u30d8\u30ea\u30ab\u30fc\u30bc\u30e2\u30c1\u30fc\u30d5\u3092\u542b\u3080\u3001\u3055\u307e\u3056\u307e\u306a\u90e8\u5206\u306b\u5909\u7570\u304c\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u907a\u4f1d\u5b50\u306e\u4e2d\u3067\u30011\u3064\u306e\u6a5f\u80fd\u3092\u7279\u5fb4\u3065\u3051\u308b\u914d\u5217\u30d1\u30bf\u30fc\u30f3\u306e\u3053\u3068\u3092\u3001\u30e2\u30c1\u30fc\u30d5\u3068\u547c\u3073\u307e\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>WRN \u30d8\u30ea\u30ab\u30fc\u30bc\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306b\u3088\u3063\u3066\u3001WRN \u30d8\u30ea\u30ab\u30fc\u30bc\u304c\u6a5f\u80fd\u3057\u306a\u304f\u306a\u308a\u3001\u6b63\u5e38\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u6a5f\u80fd\u3092\u5931\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u3001\u30a6\u30a7\u30eb\u30ca\u30fc\u75c7\u5019\u7fa4\u306e\u767a\u75c7\u539f\u56e0\u3067\u3042\u308b\u3068\u3001\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u767a\u75c7\u5e74\u9f62\u306f21\uff5e58 \u6b73\u3067\u3001\u4e00\u822c\u7684\u306b\u4f4e\u8eab\u9577\u300120\u6b73\u9803\u304b\u3089\u767d\u9aea\u3001\u982d\u9aea\u304c\u629c\u3051\u308b\u3001\u3068\u304c\u3063\u305f\u9f3b\u3001\u5c0f\u3055\u306a\u53e3\uff08\u9ce5\u306e\u3088\u3046\u306a\u9854bird-like face) \u3001\u58f0\u5e2f\u304c\u840e\u7e2e\u3059\u308b\u305f\u3081\u58f0\u304c\u9ad8\u304f\u306a\u308b\u306a\u3069\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u4f53\u5e79\u306e\u76ae\u4e0b\u8102\u80aa\u306f\u591a\u3044\u3082\u306e\u306e\u3001\u56db\u80a2\u306f\u7d30\u304f\u3001\u56db\u80a2\u672b\u7aef\u306e\u76ae\u4e0b\u8102\u80aa\u306f\u6e1b\u5c11\u3057\u3066\u3001\u76ae\u819a\u304c\u786c\u304f\u306a\u308a\u3001\u8db3\u306e\u5e95\u304c\u786c\u304f\u306a\u308a\u3001\u3072\u3056\u304b\u3089\u8db3\u9996\u307e\u3067\u306b\u6f70\u760d\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u82e5\u5e74\u6027\u767d\u5185\u969c\u3084\u3001\u6027\u817a\u6a5f\u80fd\u306e\u4f4e\u4e0b\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002\u7532\u72b6\u817a\u764c\u3084\u9ac4\u819c\u816b\u306a\u3069\u3092\u3001\u767a\u75c7\u3059\u308b\u983b\u5ea6\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>X\u7dda\u691c\u67fb\u3092\u3059\u308b\u3068\u3001\u30a2\u30ad\u30ec\u30b9\u8171\u306e\u77f3\u7070\u5316\u3001\u4e21\u624b\u4e21\u8db3\u306e\u5148\u7aef\u90e8\u5206\u306b\u9aa8\u7c97\u9aea\u75c7\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u60a3\u8005\u306e\u5e73\u5747\u6b7b\u4ea1\u5e74\u9f62\u306f47 \u6b73\u524d\u5f8c\u3067\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u60aa\u6027\u816b\u760d\u3001\u8133\u8840\u7ba1\u969c\u5bb3\u304c\u4e3b\u306a\u6b7b\u56e0\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff08C.W.Otto Werner\u306f\u30c9\u30a4\u30c4\u306e\u533b\u5e2b\u30011879\u5e74\uff5e1936\u5e74\uff09<\/p>\n<p>&nbsp;<\/p>\n<h3>\u30ed\u30b9\u30e0\u30f3\u30c8\u30fb\u30c8\u30e0\u30bd\u30f3\u75c7\u5019\u7fa4<\/h3>\n<p>\u65e9\u8001\u75c7\u5019\u7fa4\u306e\u6b21\u306f\u3001\u300c\u30ed\u30b9\u30e0\u30f3\u30c8\u30fb\u30c8\u30e0\u30bd\u30f3\u75c7\u5019\u7fa4\u300d\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2231\" src=\"http:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/118e758dcabab9beb347601422720e5b.png\" alt=\"\" width=\"300\" height=\"378\" srcset=\"https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/118e758dcabab9beb347601422720e5b.png 863w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/118e758dcabab9beb347601422720e5b-119x150.png 119w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/118e758dcabab9beb347601422720e5b-768x967.png 768w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\u51fa\u5178\uff1a\u5357\u5c71\u5802 \u533b\u5b66\u5927\u8f9e\u5178 2615\u30da\u30fc\u30b8<\/p>\n<p>&nbsp;<\/p>\n<p>1868\u5e74\u306bRothmund\u304cBavarian\u6751\u3067\u3001\u6210\u9577\u9045\u5ef6\u30fb\u767d\u5185\u969c\u3092\u4f34\u3063\u305f\u591a\u5f62\u76ae\u819a\u840e\u7e2e\u3092\u793a\u305910 \u4eba\u306e\u5b50\u3069\u3082\u305f\u3061\u3092\u5831\u544a\u3057\u30011936\u5e74\u306bThomson\u304c\u3001\u540c\u69d8\u306b\u6210\u9577\u9045\u5ef6\u30fb\u9aa8\u6b20\u640d\u3092\u4f34\u3063\u305f\u3001\u591a\u5f62\u76ae\u819a\u840e\u7e2e\u3092\u793a\u3059\u60a3\u8005\u3092\u5831\u544a\u3057\u305f\u3053\u3068\u306b\u59cb\u307e\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u5e38\u67d3\u8272\u4f53\u306b\u304a\u3051\u308b\u52a3\u6027\u907a\u4f1d\u75be\u60a3\u3067\u3001\u5149\u7dda\u306b\u3088\u308a\u60aa\u5316\u3059\u308b\u9854\u9762\u306e\u7d05\u6591\u3084\u6c34\u5e96\u304c\u751f\u3058\u3066\u3001\u8272\u7d20\u6591\u30fb\u6bdb\u7d30\u8840\u7ba1\u62e1\u5f35\u3092\u4f34\u3046\u591a\u5f62\u76ae\u819a\u840e\u7e2e\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u76ae\u819a\u75c7\u72b6\u4ee5\u5916\u306b\u3082\u3001\u767a\u9054\u9045\u6ede\u30fb\u4f4e\u8eab\u9577\u30fb\u767d\u5185\u969c\u30fb\u60aa\u6027\u816b\u8569\uff08\u6709\u68d8\u7d30\u80de\u764c\u3001\u9aa8\u8089\u816b\u306a\u3069\uff09\u306e\u5408\u4f75\u304c\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u539f\u56e0\u907a\u4f1d\u5b50\u306f\u3001\u5927\u8178\u83cc\u306e\u30d8\u30ea\u30ab\u30fc\u30bcRecQ\u306e\u30db\u30e2\u30ed\u30b0\u3067\u3042\u308b\u3001RECQL4\u3067\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u30db\u30e2\u30ed\u30b0\u3068\u306f\u3001\u540c\u3058\u7956\u5148\u304b\u3089\u6d3e\u751f\u3057\u305f\u907a\u4f1d\u5b50\u306e\u3053\u3068\u3067\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>RTS\uff08\u30ed\u30b9\u30e0\u30f3\u30c8\u30fb\u30c8\u30e0\u30bd\u30f3\u75c7\u5019\u7fa4\uff09\u306f\u3001RECQL4\u306b\u7a81\u7136\u5909\u7570\u306e\u306a\u3044I\u578b\u3068\u3001\u7a81\u7136\u5909\u7570\u3092\u8a8d\u3081\u308bII\u578b\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002\u4e21\u65b9\u306e\u578b\u3067\u591a\u5f62\u76ae\u819a\u840e\u7e2e\u3001\u767a\u9054\u9045\u5ef6\u3001\u4f4e\u8eab\u9577\u306a\u3069\u306e\u75c7\u72b6\u306f\u5171\u901a\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u767d\u5185\u969c\u306fI\u578b\u306e\u307f\u3067\u3001\u9aa8\u8089\u816b\u306fII\u578b\u306e\u307f\u3067\u8a8d\u3081\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>RECQL4\u304c\u3001\u30d2\u30c8\u3067\u30d8\u30ea\u30ab\u30fc\u30bc\u3068\u3057\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u660e\u3067\u3059\u304c\u3001DNA\u8907\u88fd\u306e\u521d\u671f\u6bb5\u968e\u306a\u3089\u3073\u306b\u8ee2\u5199\u3084DNA\u4fee\u5fa9\u306b\u3001\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>RTS \u304c\u3001\u306a\u305c\u5149\u7dda\u904e\u654f\u75c7\u72b6\u3092\u793a\u3059\u306e\u304b\u3001\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u7d2b\u5916\u7dda\u306b\u3088\u308bDNA\u640d\u50b7\u306e\u4fee\u5fa9\u306b\u3001\u969c\u5bb3\u304c\u3042\u308b\u4f8b\u3082\u5b58\u5728\u3057\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff08August von&nbsp; Rothmund\u306f\u30c9\u30a4\u30c4\u306e\u773c\u79d1\u533b\u30011830 &#8211; 1906 ; Matthew Sydney Thomson \u306f\u30a4\u30ae\u30ea\u30b9\u306e\u76ae\u819a\u79d1\u533b\u30011894 &#8211; 1969\uff09<\/p>\n<p>&nbsp;<\/p>\n<h2>\u751f\u307e\u308c\u3064\u304d\u306e\u767d\u9aea\u4f53\u8cea\uff5e\u30ef\u30fc\u30eb\u30c7\u30f3\u30d6\u30eb\u30b0\u75c7\u5019\u7fa4<\/h2>\n<p>\u751f\u307e\u308c\u3064\u304d\u306e\u767d\u9aea\u4f53\u8cea\u3001\u6700\u5f8c\u306f\u300c\u30ef\u30fc\u30eb\u30c7\u30f3\u30d6\u30eb\u30b0\u75c7\u5019\u7fa4\u300d\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2232\" src=\"http:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/a44a59e6109162de2230e68fdf89a605.png\" alt=\"\" width=\"400\" height=\"365\" srcset=\"https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/a44a59e6109162de2230e68fdf89a605.png 1095w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/a44a59e6109162de2230e68fdf89a605-150x137.png 150w, https:\/\/xn--rov785aa3148a.com\/wp-content\/uploads\/2017\/05\/a44a59e6109162de2230e68fdf89a605-768x701.png 768w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/>\u51fa\u5178\uff1a\u5357\u5c71\u5802 \u533b\u5b66\u5927\u8f9e\u5178 2626\u30fb2627\u30da\u30fc\u30b8<\/p>\n<p>&nbsp;<\/p>\n<p>\u767d\u9aea\uff08\u524d\u9aea\u306e\u4e00\u90e8\uff09\u3001\u5de6\u53f3\u306e\u5149\u5f69\u306e\u8272\u304c\u7570\u306a\u308b\u3001\u767d\u6591\u3001\u8272\u7d20\u6c88\u7740\u306a\u3069\u306e\u8272\u7d20\u7570\u5e38\u3001\u611f\u97f3\u6027\u96e3\u8074\u3092\u3001\u4e3b\u306a\u75c7\u72b6\u3068\u3059\u308b\u907a\u4f1d\u6027\u306e\u75be\u60a3\u3067\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u8033\u306e\u5668\u5b98\u306f\u3001\u5927\u304d\u304f\u5916\u8033\u30fb\u4e2d\u8033\u30fb\u5185\u8033\u306b\u308f\u304b\u308c\u3001\u5916\u8033\u30fb\u4e2d\u8033\u306f\u97f3\u3092\u5185\u8033\u306b\u9001\u308a\u3001\u5185\u8033\u306f\u97f3\u3092\u96fb\u6c17\u4fe1\u53f7\u306b\u5909\u3048\u3066\u8133\u306b\u9001\u308a\u307e\u3059\u3002\u96e3\u8074\u306f\u3001\u4f1d\u97f3\u6027\u96e3\u8074\u3068\u611f\u97f3\u6027\u96e3\u8074\u306b\u5206\u304b\u308c\u3001\u4f1d\u97f3\u6027\u96e3\u8074\u306f\u5916\u8033\u30fb\u4e2d\u8033\u306e\u969c\u5bb3\u3067\u3001\u611f\u97f3\u6027\u96e3\u8074\u306f\u5185\u8033\u306e\u969c\u5bb3\u3067\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u81e8\u5e8a\u75c7\u72b6\u306e\u9055\u3044\u304b\u3089\u3001I\u3001ll a\u3001llb,\u3001\u2162\u3001\u2163\u578b\u306e5 \u578b\u306b\u5206\u3051\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u5185\u773c\u89d2\u89e3\u96e2\uff08\u5de6\u53f3\u306e\u76ee\u306e\u9593\u9694\u304c\u5e83\u3044\uff09\u3092\u3068\u3082\u306a\u3046\u3001\u5e38\u67d3\u8272\u4f53\u306b\u304a\u3051\u308b\u512a\u6027\u907a\u4f1d\u3067\u3042\u308bI \u578b\u304c\u591a\u304f\u3001\u540c\u3058\u5bb6\u7cfb\u306e\u4e2d\u3067\u3082\u73fe\u308c\u65b9\u306e\u9055\u3044\u304c\u5927\u304d\u3044\u75be\u60a3\u3067\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u751f\u547d\u306b\u304b\u304b\u308f\u308b\u969c\u5bb3\u306f\u5c11\u306a\u304f\u3001\u96e3\u8074\u306b\u5bfe\u3059\u308b\u6559\u80b2\u652f\u63f4\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n<p>\u767a\u75c7\u306e\u983b\u5ea6\u306f\u7d043\u4e07\u4eba\u306b1\u4eba\u3067\u3001\u5148\u5929\u6027\u611f\u97f3\u6027\u96e3\u8074\u8005\u306e1\uff5e3 \uff05\u306b\u307f\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u75be\u60a3\u306e\u539f\u56e0\u306f\u3001\u795e\u7d4c\u5824\u7d30\u80de\u79fb\u52d5\u306e\u79fb\u52d5\u969c\u5bb3\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\uff08\u88dc\u8db3\uff1a\u795e\u7d4c\u5824\u7d30\u80de\u306f\u3001\u4f53\u4e2d\u306b\u5206\u6563\u3057\u3066\u81ea\u5f8b\u795e\u7d4c\u7cfb\u3084\u982d\u84cb\u9aa8\u306a\u3069\u591a\u304f\u306e\u7d44\u7e54\u3092\u4f5c\u308a\u51fa\u3059\u7d30\u80de\u3067\u3059\u3002\uff09<\/p>\n<p>&nbsp;<\/p>\n<p>\u5e38\u67d3\u8272\u4f53\u306b\u304a\u3051\u308b\u512a\u6027\u907a\u4f1d\u3067\u3042\u308b\u3001I \u578b\u3068\u2162\u578b\u306fPAX3 \uff08\u907a\u4f1d\u5b50\u5ea72q35) \u306e\u7570\u5e38\u3001lla\u578b \u306fMITF 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